Tuesday, August 6, 2019

Cyanocobalamin

Cyanocobalamin is a manufactured form of vitamin B 12. It used to treat vitamin B12 deficiency. This may occur in pernicious anemia and  bowel cancer.It is used by mouth, by injection into a muscle.


Possible side effects of cyanocobalamin injection include allergic reactions such as hives, difficult breathing; redness of the face; swelling of the arms, hands, feet, ankles or lower legs; extreme thirst; and diarrhoea. Less-serious side effects may include headache, dizziness, leg pain, itching, or rash.Cyanocobalamin is one of the most widely manufactured vitamers in the vitamin B
12  family  because cyanocobalamin is the most air-stable of the B 12 forms. It is the easiest[citation needed] to crystallize and therefore easiest  to purify after it is produced by bacterial fermentation, or synthesized in vitro. It can be obtained as dark red crystals or as an amorphous red powder. Cyanocobalamin is hygroscopic in the anhydrous form, and sparingly soluble in water. Cyanocobalamin is commercially prepared by bacterial fermentation. Fermentation by a variety of microorganisms yields a mixture of methyl-, hydroxo- and adenosylcobalamin. These compounds are converted to cyanocobalamin by addition of potassium cyanide in the presence of sodium nitrite and heat.



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